Yes, head loss related to elevation required to pump back to display as well as fittings (especially ball valves) all of which add to back pressure by restricting flow through. Your main limiting factor will be the size of return(s) and which type of system you prefer. I am a strong believer in high-flow sump/fuges and have approx 1050+-gph running through my sump/fuge utilyzing a Panworld 100PX-X which without head-loss starts out at 1270gph and goes up 4' with a handfull of fittings in between. This is on my 125g with 75g sump/fuge, DT has two 1-1/2" drains with two 3/4" emergency overflows.
Cheers, Todd