Actually after posting this thread I stopped using IOs Reef Crystals completely. Reason being is I found exactly what Boomer mentioned. One batch of Reef Crystlas with ~420 Ca and the next with 350!
Not only did the one batch have 350, but after doing a water change EVERYthing in my mixed reef looked like crap and started to close up. Too many factors to pin point it for 100% surety on the salt, but it made me look at it again. The main reason I switched off is because if Ca has such variance from batch to batch I'm worried about the other elements including Iodine which if it swings too much could have a strong negative impact on my corals.
I've switched to Tropic Marin Pro and love it, however now examining Brightwell’s salt as well.