Let me clarify a few things. ORP = oxidation reduction potential. If you think of the ORP as a battle, you don't want either the oxidizers or the reducers to win. If either wins....that means your tank will be dead. The range of ORP 250-500 is important to note because if you are measuring ORP - you will want your value ~375. Also remember, a value of 250 is just as bad as a value of 500....again, you don't want either to win......you want a balance. The higher the ORP value, the greater oxidation ---> greater reduction potential. There are some members of each team that could be considered the star....for example: ozone is a big oxidizer. Hydrogen peroxide (H2O2) is also an oxidizer, sometimes referred to as "poor man's ozone". An oxidizing agent (electron acceptor) is a reactant that accepts electrons from another reactant. By contrast, the reducing agent (electron donor) is a reactant that donates electrons to another substance to reduce the oxidation state of one of its atoms. We can look at bacteria as one form of a reducer. So let's say you stick your ORP probe into a DSB....your ORP will drop, and continue the deeper you go. Using jase0723 as an example, when the sand bed was removed, the ORP (potential for reduction) increased quite a bit....makes sense because a large number of reducers were removed from the system. Same thing with a skimmer. Your skimmer gets covered in algae and other organic material, there will be reducers present, so....clean off your skimmer, you are removing the reducers present. Do you need ORP to know when it is time to clean your skimmer? IMO, no - you probably could just look at it and see when it is time. Can you use ORP as an indicator of water quality? I guess if you have a lot of decaying matter in your tank, you will have a larger number of reducers present - lowering the reduction potential. One last point - oxidizers and oxygenation are two different things.