When you go big, there is noooo looking back !!
When I got my 375g system, there were two things that I carefully decided on.
1. Don't go cheap on a skimmer
2. Automate water change system.
I have both, and they have served me well.
The skimmer is the lifeline of your system. Depending on your fish bioload, research and get the best damn skimmer you can afford; you might send a Pm to Skimerwhisperer he is the guru of skimmers.
Also, if you can, automate your water changes so that you can ENJOY your big system, instead of having to clean/maintain it every other day.
this is my .02